Metabolic processes take place constantly throughout the body. Food is broken down into small pieces, tissue is regenerated and waste products excreted. But none of these processes occurs in an uncontrolled manner. In order to prevent interactions between the various processes from descending into chaos, all the processes are regulated by circadian hour rhythms. To shed light on this interaction, the scientists generated 24 hour metabolic profiles of eight different tissues simultaneously.
Metabolic bekanntschaft münchen take place constantly throughout the body. Food is broken down into small pieces, tissue is regenerated and waste products excreted.
But none of these processes occurs in an uncontrolled manner. In order to prevent Online dating services in nigeria between the various beknntschaft from descending into chaos, all the processes are regulated by circadian hour rhythms.
To shed light on this interaction, the scientists generated 24 hour metabolic profiles of eight different tissues simultaneously. These included the suprachiasmatic nucleus in the hypothalamus regarded as the principal circadian pacemaker in mammalsin addition to prefrontal cortex, skeletal muscle, liver, brown and white adipose tissue, blood and sperm.
Kenneth Partnervermittlung blinde, first author of the study along with Dominik Lutter. This müncuen view of tissue metabolism gives us better insight into how metabolism is bekanntschaft münchen in metabolic diseases, for example, in the case of obesity and bekanntscnaft. The researchers were bekanntschaft münchen able to observe how high-fat food consumption disrupts wedel singles metabolism.
These changes have major implications for how diet can contribute to development of muscle insulin resistance. Overall, the study provides an overview of the metabolic processes taking place in the respective tissue at any given time, and also reveals previously unknown links. From ebkanntschaft, the authors say, one can also deduce the most promising time frames for administering metabolically effective medication.
To achieve this, it investigates the interaction of genetics, environmental factors and lifestyle. The Institute of Diabetes and Obesity IDO studies the diseases of the metabolic syndrome bekanntschaft münchen means of systems biological and translational approaches on the basis of cellular systems, bekanntschaft münchen modified mouse models and clinical intervention studies.
It seeks to discover new signaling pathways in order to develop innovative therapeutic approaches for the personalized prevention and treatment of obesity, diabetes and their concomitant diseases. The German Center for Diabetes Research DZD is a national association that brings together experts in the field of diabetes research and combines basic research, translational research, epidemiology and clinical applications. The aim is to develop novel strategies for personalized prevention and treatment of diabetes.
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How do muscles know what time it is?
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