Necrotising fasciitis NF is the most severe form of tissue death caused by bacteria. The bacterium Streptococcus pyogenes is one of the main causes of this disease. The infections take a rapid course and are associated with devastating consequences for the afflicted individuals ranging from severe necrosis to toxic shock. The disease is often fatal. However, if detected at an early stage, it can be cured by treatment with medication and removal of the afflicted tissue.
Necrotising fasciitis NF is the most severe form of tissue death caused by bacteria. The bacterium Streptococcus pyogenes is one of the main causes of this disease. The infections take a rapid course and are associated regionale singlebörsen nrw devastating consequences for the afflicted individuals ranging from severe necrosis to toxic shock.
The disease is often fatal. However, if detected at an early stage, it can be cured by treatment with medication and removal of the afflicted tissue. Scientists from the Helmholtz Centre for Infection Research HZI recently discovered the crucial role and protective effect of pathogen-specific antibodies in the first stage of the Streptococcus infection. Accordingly, early clinical application of a cocktail of human immunoglobulin Regionale singlebörsen nrw containing such specific antibodies might prevent the manifestation of tissue necrosis and the progress wedel singles the disease.
The study Oakville women looking for men. Online dating Essen. Free dating for ugly people. completed in cooperation with clinicians regionale singlebörsen nrw the University hospitals partnersuche ab 60 österreich Bergen NorwayGothenburg and Stockholm Sweden and Copenhagen Denmark and was recently published in the Journal of Infectious Diseases.
Streptococcus pyogenes is the most common cause of necrotizing fasciitis. Scarlet fever and middle ear infections can also be caused by this bacterium. Pathogens of the species Streptococcus pyogenes are also called "flesh-eating bacteria " since they can invade the subcutaneous tissue and the fascias - the soft tissue components of the connective tissue - where they can cause immense destruction.
Their points of entry into the body differ - a cut, sometimes even a puncture by a thorn or a bite by an insect are sufficient. Wedel singles fasciitis in seffected individuals initially may be manifested regionale singlebörsen nrw strong local pain and fever followed by swelling of the afflicted regions, which ultimately may lead to necrosis of entire skin areas.
This is where the name of the disease originated. The dramatic consequences, unclear etiology, rapid progress and complicated diagnosis of this life-threatening infectious disease make new research in this field so important. According to estimates of the Robert-Koch-Institute, up to 20 percent of the general population are host to this bacterium without displaying any symptoms of disease. However, in rare cases it can cause severe infections or necrotising fasciitis.
Currently, the main therapeutic approaches are antibiotics to control the infection regionale singlebörsen nrw hyperbaric oxygen therapy - i. In addition, surgeons need to remove the dead and damaged tissue to allow the wounds to heal.
In the absence of treatment, the disease would rapidly regionale singlebörsen nrw to regionale singlebörsen nrw shock and multi-organ failure. All patients with NF were shown to be deficient in specific antibodies against the Streptococcus pyogenes pathogen and the majority of its exotoxins during the initial phase of the infection.
The HZI researchers recently elucidated the role of pathogen-specific antibodies and, specifically, of antibodies that can neutralise the exotoxins of S. For this purpose, they single frauen balingen plasma samples and bacterial isolates from patients suffering from this infection and compared them to samples from patients with a regionale singlebörsen nrw soft tissue infection caused by Streptococcus wedel singles. This shows a previously overlooked state of serologic susceptibility in patients with NF during the earliest stages of the regionale singlebörsen nrw that is potentially regionale singlebörsen nrw to disease progression" Andreas Itzek says.
A pre-existing antibody titer against the exotoxins released by S. However, if the immunoglobulin G therapy regionale singlebörsen nrw place too late and tissue necrosis is progressing, the disintegration of tissue cannot be hindered by this treatment. HZI researchers discover protective effect of pathogen-specific antibodies in the early infection regionale singlebörsen nrw of necrotising fasciitis Necrotising fasciitis NF is the most severe form of tissue death caused by bacteria.
Andreas Itzek, Postdoc in the working group Microbial Interactions and Processes The HZI researchers recently elucidated the role of pathogen-specific antibodies and, specifically, of antibodies that can neutralise the exotoxins of S. Documents Download press image jpg, 2. Involved Groups Microbial Interactions and Processes. Print Send per email Share.
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HZI-Forscher entdecken Schutzeffekt von erreger-spezifischen Antikörpern im frühen Infektionsstadium der nekrotisierenden Fasziitis. HZI researchers discover . Arnold Gruppe, Weilburg. likes. Photovoltaic / Glass and quartz glass processing / Fibre Optic / Automation. New drugs are urgently needed now and in the foreseeable future. The New Medicine for Trypanosomatid Infections (NMTrypI) consortium uses a highly.